A. peer-reviewed papers
Publications
2018
1. Weng WT, Wu CS, Wang FS, Wu CY, Ma YL, Chan HH, Wu DC, Wu JC, Chu TH, Huang SC, Tai MH. α-Melanocyte-Stimulating Hormone Exacerbates Angiogenesis by Inducing Nitric Oxide Deficiency through PKA/NFκB Signaling. Int J Mol Sci. 2018, 19(12), 3823;
2. Tsai WK, Wang CI, Liao CH, Yao CN, Kuo TJ, Liu MH, Hsu CP, Lin SY, Wu CY, Pyle J, Chen J and Chan YH. Molecular Design of Near-Infrared Fluorescent Pdots for Tumor Targeting: Aggregation-Induced Emission versus Anti-Aggregation Caused Quenching. Chem. Sci. 2018, Accepted
3. Feng-Chi Hsieh, Wangta Liu, Kai-Chun Cheng, Chang-Yi Wu, Yen-Chun Chen, Ching-Chuan Chen, Chun-Tzu Hung and Chien-Chih Chiu. Protective effects of Lycium barbarum extracts on UVB-induced damage in human retinal pigment epithelial cells accompanied by attenuating ROS and DNA damage. Oxidative Med and Cellular Longevity. 2018 Nov 2018(9):1-12.
4. Chien CM; Pin-Hsuan Wu; Juan-Cheng Yang; Wu CY; Guan-Yu Chen; Yang-Chang Wu; Chou CK; Tseng CH; Chen YL; Wang LF; Chiu CC. Phytochemical Naphtho[1,2-b] furan-4,5-dione (NFD) Induced Topoisomerase II-mediated DNA Damage Response in Human Non-small-Cell Lung Cancer. Phytomedicine. 2018.11 accepted.
5. Chang YC, Fong Y, Tsai EM, Chang YG, Chou HL, Wu CY, Teng YN, Liu TC, Yuan SS, Chiu CC. Exogenous C₈-Ceramide Induces Apoptosis by Overproduction of ROS and the Switch of Superoxide Dismutases SOD1 to SOD2 in Human Lung Cancer Cells. Int J Mol Sci. 2018 Oct 2;19(10).
6. Jen-Yang Tang, Chang-Yi Wu, Chih-Wen Shu, Sheng-Chieh Wang, Meng-Yang Chang, Hsueh-Wei Chang. A novel sulfonyl chromen-4-ones (CHW09) selectively targets oral cancer cells showing apoptosis, oxidative stress, and DNA damage. Environ Toxicol. 2018 Nov; 33(11): 1195- 1203.
7. Chiu YH, Hsu SH, Hsu HW, Huang KC, Liu W, Wu CY, Huang WP, Chen JY, Chen BH, Chiu CC. Human non‑small cell lung cancer cells can be sensitized to camptothecin by modulating autophagy. Int J Oncol. 2018 Nov;53(5):1967-1979.
2017
9. Song YC*, Wu BJ*, Chiu CC*, Chen CL, Zhou JQ, Liang SR, Duh CY, Sung PJ, Wen ZH, and Wu CY#. Coral-derived natural marine compound GB9 impairs vascular development in zebrafish. Int J Mol Sci. 2017 Aug 3;18(8).1696 (#corresponding author)
8. Chen HM*, Wu CY*, Chen JJ, Wu DC, Liu MY, Huang YB, Huang HT, Sun WC, Shu CW, Chen CL, (2017) Mechanical Strain Enhances TGF-β Responsiveness by Altering TGF-β Receptor Partitioning Between Submembrane Microdomains in Vascular Smooth Muscle Cells. Journal of Biomaterials and Tissue Engineering. 7, 1028–1037. (*Co-first author)
7. Chou HL, Fong Y, Wei CK, Tsai EM, Chen JY, Chang WT, Wu CY, Huang HW, Chiu CC. A Quinone-Containing Compound Enhances Camptothecin-Induced Apoptosis of Lung Cancer Through Modulating Endogenous ROS and ERK Signaling. Arch Immunol Ther Ex (Warsz). 2017 Jun;65(3):241-252
6. Wu TY*, Wang YS*, Song YC, Chen ZY, Chen YT, Chiu CC and Wu CY#. Fine-tune regulation of carboxypeptidase N1 controls vascular patterning during zebrafish development. Scientific Reports 2017. May. 7:1852 (#corresponding author)
5. Chang YT, Wu CY, Tang JY, Huang CY, Liaw CC, Wu SH, Sheu JH*, Chang HW*. Sinularin Induces Oxidative Stress-Mediated G2/M Arrest and Apoptosis in Oral Cancer Cells. Environ Toxicol. 2017 Sep;32(9):2124-2132.
4. Huang PC*, Chiu CC*, Chang HW*, Wang YS, Syue HH, Song YC, Wen ZH, , Tai MH and Wu CY#.. PrdxI-encoded peroxiredoxin is important for vascular development in zebrafish. FEBS Lett. 2017 Feb 23. (#corresponding author)
3. Yao Fong*, Wu CY*, Chang KF, Chen BH, Chou WJ, Tseng CH, Chen YC, Wang HM, Chen YL*, Chiu CC*. Dual roles of extracellular signal-regulated kinase (ERK) in quinoline compound BPIQ induced apoptosis and anti-migration of human non-small cell lung cancer cells. Cancer Cell International. 2017 Mar 7;17:37. (*Co-first author)
2. Chang HW*, Wang WD*, Chiu CC, Chen CH, Wang YS, Chen ZY, Liu W, Tai MH, Wen ZH and Wu CY#. Ftr82 is critical for vascular patterning during zebrafish development. Int. J. Mol. Sci. 2017, 18(1), 156 (#corresponding author)
1. Wang WD, Li YF, Hsu HJ, and Wu CY. Retinoic acid protects and rescues the development of zebrafish embryonic retinal photoreceptor cells from exposure to Paclobutrazol. Int J Mol Sci. 2017 Jan 11;18(1).
2016 (hightline papers)
5. Chou HL, Fong Y, Lin HH, Tsai EM, Chen YF, Chang WT, Wu CY, Wang HM, Huang HW and Chiu CC “An acetamide derivative as a camptothecin sensitizer for human non-small cell lung cancer cells through increased oxidative stress and JNK activation". Oxidative Medicine and Cellular Longevity. 2016:9128102.
4. Lamont RE*, Wu CY*, Ryu JR, Vu W, Davari P, Sobering RE, Kennedy RM, Munsie NM, Childs SJ. The LIM-homeodomain transcription factor Islet2a promotes angioblast migration. Dev Biol. 2016 Jun 15;414(2):181-92. *co-first authors
3. Fong Y, Tang CC, Hu HT, Fang HY, Wu CY, Yuan SS, Wang HM, Chen YC, Teng YN and Chiu CC. The inhibitory effect of trans-Ferulic acid on proliferation and migration of human lung cancer cells through modulating endogenous ROS and beta-catenin activity. Chinese Medicine, 2016 Oct 1;11:45.
2. Chang HS, Tang JY, Yen CY, Huang HW, Wu CY, Chung YA, Wang HR, Chen IS, Huang MY, Chang HW. Antiproliferation of Cryptocarya concinna-derived cryptocaryone against oral cancer cells involving apoptosis, oxidative stress, and DNA damage. BMC Complement Altern Med. 2016 Mar 8;16(1):94.
1. Liou SY, Ke CS, Chen JH, Luo YW, Kuo SY, Chen YH, Fang YH, Wu CY, Chiang CM and Chan YH. Tuning the Emission of Semiconducting Polymer Dots from Green to Near-Infrared by Alternating Donor Monomers and their Applications for In Vivo Biological Imaging. ACS Macro Lett., 2016, 5 (1), pp 154–157
2015 (hightline papers)
7. Lin KY, Kao SH, Lai CM, Chen CT, Wu CY, Hsu HJ, Wang WD. Tumor Suppressor Lzap Suppresses Wnt/β-catenin signaling to Promote Zebrafish Embryonic Ventral Cell Fates via the Suppression of Inhibitory Phosphorylation of GSK3. J Biol Chem. 2015, Dec, 290(50):29808-19.
6. Li RF*, Wu TY*, Mou YZ, Wang YS, Chen CL and Wu CY#. Nr2f1b control venous specification and angiogenic patterning during zebrafishvascular development. J Biomed Sci. 2015, Nov., 17;22:104. #corresponding author
5. Chiu CC, Chang KF, Chen BH, Chou HL, Tseng CH, Fong Y, Fu TF, Chang HW, Wu CY, Lin SR, Chen YL. BPIQ, a novel synthetic quinoline
derivative, 1 inhibits growth and induces mitochondrial apoptosis of lung cancer cells in vitro and in zebrafish xenograft model. BMC cancer. 2015, Nov. 15:962.
4. Liu HY, Wu PJ, Kuo SY, Chen CP, Chang EH, Wu CY, Chan YH. Quinoxaline-Based Polymer Dots with Ultrabright Red to Near-Infrared Fluorescence for In Vivo Biological Imaging. J Am Chem Soc. 2015 Aug. 137(32):10420-9.
3. Chou CK, Wu CY, Chen JY, Ng MC, Wang HM, Chen JH, Yuan SS, Tsai EM, Chang JG, Chiu CC. BubR1 Acts as a Promoter in Cellular Motility of Human Oral Squamous Cancer Cells through Regulating MMP-2 and MMP-9. Int J Mol Sci. 2015 Jul 3;16(7):15104-17.
2. Lin SW, Huang SC, Kuo HM, Chen CH, Ma YL, Chu TH, Bee YS, Wang EM, Wu CY, Sung PJ, Wen ZH, Wu DC, Sheu JH, Tai MH. Coral-derived compound WA-25 inhibits angiogenesis by attenuating the VEGF/VEGFR2 signaling pathway. Mar Drugs. 2015 Feb 6;13(2):861-78.
1. Wang WD, Chen GT, Hsu HJ, Wu CY. Aryl hydrocarbon receptor 2 mediates the toxicity of Paclobutrazol on the digestive system of zebrafish embryos. Aquat Toxicol. 2015 Feb;159:13-22.
2014 (hightline papers)
8. Wu CY*, Lin MW*, Wu DC, Huang YB, Huang HT, Chen CL. The role of phosphoinositide-regulated actin reorganization in chemotaxis and cell migration. Br J Pharmacol. 2014 Dec;171(24):5541-54. first author
7. Yen YH, Farooqi AA, Li KT, Butt G, Tang JY, Wu CY, Cheng YB, Hou MF, Chang HW. Methanolic Extracts of Solieria robusta Inhibits Proliferation of Oral Cancer Ca9-22 Cells via Apoptosis and Oxidative Stress. Molecules. 2014 Nov 14;19(11):18721-32.
6. Ma YL, Lin SW, Fang HC, Chou KJ, Bee YS, Chu TH, Chang MC, Weng WT, Wu CY, Cho CL, Tai MH. A novel poly-naphthol compound ST104P suppresses angiogenesis by attenuating matrix metalloproteinase-2 expression in endothelial cells. Int J Mol Sci. 2014 Sep 19;15(9):16611-27.
5. Wu BJ, Chiu CC, Chen CL, Wang WD, Wang JH, Wen ZH, Liu W, Chang HW and Wu CY*. Nr2fIa is required for vascular development in zebrafish. PLoS One. 2014 Aug 26;9(8):e105939. *corresponding author
4. Fong Y, Lin YC, Wu CY, Wang HM, Lin LL, Chou HL, Teng YN, Yuan SS, Chiu CC. The antiproliferative and apoptotic effects of sirtinol, a sirtuin inhibitor on human lung cancer cells by modulating Akt/β-catenin-Foxo3a axis. Scientific World Journal. 2014:937051.
3. Huang SY, Feng CW, Hung HC, Chakraborty C, Chen CH, Chen WF, Jean YH, Wang HM, Sung CS, Sun YM, Wu CY, Liu W, Hsiao CD, Wen ZH. A novel zebrafish model to provide mechanistic insights into the inflammatory events in carrageenan-induced abdominal edema. PLoS One 2014 Aug 20;9(8):e104414. (IF= 3.730; subject categories Multidisciplinary Sciences 7/56=12.5%)
2. Weng WT, Huang SC, Ma YL, Chan HH, Lin SW, Wu JC, Wu CY, Wen ZH, Wang EM, Wu CL, Tai MH. α-Melanocyte-stimulating hormone inhibits angiogenesis through attenuation of VEGF/VEGFR2 signaling pathway. Biochim Biophys Acta. 2014 Jun;1840(6):1850-60.
1. Lin IL, Chou HL, Lee JC, Chen FW, Fong Y, Chang WC, Huang HW, Wu CY, Chang WT, Wang HM, Chiu CC. The antiproliferative effect of C2-ceramide on lung cancer cells through apoptosis by inhibiting Akt and NFκB. Cancer Cell Int. 2014 Jan 6;14(1):1.
Before 2013
1. Lin CL, Chen RF, Chen JY, Chu YC, Wang HM, Chou HL, Chang WC, Fong Y, Chang WT, Wu CY, Chiu CC. Protective effect of caffeic acid on paclitaxel induced anti-proliferation and apoptosis of lung cancer cells involves NF-κB pathway. Int J Mol Sci. 2012;13(5):6236-45.
2. Wu CY, Roje S, Sandoval F, Bird AJ, Winge DR, Eide DJ. Repression of sulfate assimilation is an adaptive response of yeast to the oxidative stress of zinc deficiency. J Biol Chem. 2009 Oct 2;284(40):27544-56. first author
3. Wu CY, Steffen J, Eide DJ. Cytosolic superoxide dismutase (SOD1) is critical for tolerating the oxidative stress of zinc deficiency in yeast. PLoS One. 2009 Sep 16;4(9): e7061. first author
4. Qiao W, Ellis C, Steffen J, Wu CY, Eide DJ. Zinc status and vacuolar zinc transporters control alkaline phosphatase accumulation and activity in Saccharomyces cerevisiae. Mol Microbiol. 2009 Apr;72(2):320-34.
5. Wu CY, Bird AJ, Chung LM, Newton MA, Winge DR, Eide DJ. Differential control of Zap1-regulated genes in response to zinc deficiency in Saccharomyces cerevisiae. BMC Genomics. 2008 Aug 1;370(9). “Faculty of 1000 Biology” first author
6. Wu CY, Bird AJ, Winge DR, Eide DJ. Regulation of the yeast TSA1 peroxiredoxin by ZAP1 is an adaptive response to the oxidative stress of zinc deficiency. J Biol Chem. 2007 Jan 26;282(4):2184-95. “Faculty of 1000 Biology” first author
7. Herbig A, Bird AJ, Swierczek S, McCall K, Mooney M, Wu CY, Winge DR, Eide DJ. Zap1 activation domain 1 and its role in controlling gene expression in response to cellular zinc status. Mol Microbiol. 2005 Aug;57(3):834-46.
8. Wang YL, Wu CY, Chang CT, Sung HY. Invertase inhibitors from sweet potato (Ipomoea batatas): purification and biochemical characterization. J Agric Food Chem. 2003 Jul 30;51(16):4804-9.
A. Patents & Technique reports
4. 戴明泓、林士為、蕭亘邑、吳長益、鄭詩璇、戴伯翰、蔡函恩、謝佳汶、吳建慶。一種組合物用於製備促進傷口癒合之藥物的用途 USE OF A COMPOSITION FOR PREPARING A DRUG FOR ENHANCING WOUND HEALING。中華民國專利 (證書號數I578996) 公告日2017/04/21
3. 王美惠、吳長益、李德偉、黃亨通、丁幹。檢測黃麴毒素白蛋白鍵結物之放射免疫試劑套組及其用途。中華民國專利 (發明第201400號) 2004.05.01-2020.11.16
2. 吳長益、王美惠、陳敏男、李德偉。鈷標幟白蛋白及抗體之研究。INER-T2685核能研究所對內報告, 2000, 十月
1. 吳長益、王美惠。前列腺癌腫瘤標記放射免疫試劑相關專利的回顧與分析。INER-T2589核能研究所對內報告, 1999, 十二月